Xanax XR Drug Interactions

When antidepressants, barbiturates, or antipsychotic medicines are combined with Xanax XR, drug interactions can occur. These interactions can alter the amount of Xanax XR in your blood, potentially increasing your risk of side effects (such drowsiness, confusion, memory loss, or difficulty breathing). If Xanax XR drug interactions are a concern, your healthcare provider may need to monitor you more closely or may adjust your dosages.

An Overview of Xanax XR Drug Interactions

 Xanax XR® (alprazolam XR) can potentially interact with many other medications. Some of the medicines that may lead to Xanax XR drug interactions include:
 
  • Alcohol
 
 
 
 
  • Barbiturates, including:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Certain antibiotics or antifungals, including:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
 
 
 
  • Grapefruit juice
 
  • Narcotics or opiates, such as:
 
 
 
 
  • Other benzodiazepines, including:
 
 
  • Protease inhibitors, such as:
 
 
 
  • Sleep medications.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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