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Xanax XR Drug Interactions

Cimetidine
Combining Xanax XR with cimetidine can increase the amount of Xanax XR in your blood, possibly increasing your risk of side effects. Do not take these medications together without your healthcare provider's approval. Most likely, your healthcare provider will recommend taking one of the many cimetidine alternatives that do not interact with Xanax XR.
 
Delavirdine
Taking Xanax XR with delavirdine can increase the amount of Xanax XR in your blood, which may increase your risk of side effects. Your healthcare provider may need to lower your Xanax XR dosage to prevent this interaction from occurring.
 
Grapefruit Juice
Grapefruit juice can increase the level of Xanax XR in your blood, possibly increasing your risk of Xanax XR side effects. It is best to avoid grapefruit juice while taking the medication. If your healthcare provider decides that it is okay for you to drink grapefruit juice, you should do so consistently and in moderation.
 
Narcotics or Opiates
Combining an opiate or narcotic with Xanax XR can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk to your healthcare provider before taking these medications together.
 
Nefazodone
Nefazodone can double the amount of Xanax XR in your blood, greatly increasing your risk of side effects. Do not take these medications together without your healthcare provider's approval.
 
Oral Contraceptives
Taking Xanax XR with oral contraceptives (also known as birth control pills) can increase the amount of Xanax XR in your blood, which may increase your risk of side effects. Depending on your individual situation, your healthcare provider may need to lower your Xanax XR dosage or may recommend another form of birth control.
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