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Xanax XR Drug Interactions

Xanax XR Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Xanax XR is combined with any of the drugs listed above.
 
Alcohol
Combining alcohol with Xanax XR can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Because serious side effects may occur, it is best to avoid alcohol while taking Xanax XR (see Xanax and Alcohol).
 
Antidepressant Medications
Combining an antidepressant with Xanax XR can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. In addition, many antidepressants can increase the level of Xanax XR in your blood, which increases the risk of side effects even more. Make sure to talk to your healthcare provider before taking Xanax XR with an antidepressant, as you may need to be monitored more closely and may need a lower Xanax XR dosage.
 
Antipsychotic Medications
Taking an antipsychotic medication with Xanax XR can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk to your healthcare provider before combining these medications.
 
Barbiturates
Combining a barbiturate with Xanax XR can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk to your healthcare provider before taking these medications together.
 
Certain Antibiotics or Antifungals
Taking Xanax XR with certain antibiotics or antifungals can increase the amount of Xanax XR in your blood, potentially increasing your risk of side effects. In general, Xanax XR should not be taken with these medications (especially ketoconazole or itraconazole).
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