Vivitrol Drug Interactions
Your healthcare provider needs to be aware if you are using any other drugs, such as marijuana, codeine, or morphine, while receiving injections of Vivitrol. Some of these drug interactions may increase or decrease the effects of the medications. Other products that may cause interactions with Vivitrol include heroin, methadone, and hydrocodone.
Vivitrol® (naltrexone injection) may potentially react with a few other medications. Some of the medications that may lead to drug interactions with Vivitrol include but are not limited to:
- Opioids, such as:
- Fentanyl (Abstral®, Actiq®, Duragesic®, Fentora®, Lazanda®, Onsolis®, Subsys®)
- Hydromorphone ER (Exalgo®)
- Meperidine (Demerol®)
- Methadone (Diskets®, Dolophine®, Methadose®)
- Oxymorphone (Opana®) and oxymorphone ER (Opana® ER)
- Tapentadol (Nucynta®) and tapentadol ER (Nucynta® ER).
The following sections explain in detail the potentially negative reactions that can occur when Vivitrol is combined with any of the drugs listed above.
Cannabinoid are sometimes used to help relieve nausea, vomiting, and pain. Opioid antagonists, such as Vivitrol, may increase or decrease the effects of cannabinoids. Let your healthcare provider know if you are being treated with a cannabinoid or use cannabinoid products prior to starting Vivitrol treatment.
Vivitrol blocks the effects of opioids, making them less effective. If you need medication for pain, coughing, or diarrhea, you will need to take a medicine that does not contain an opioid. If an opioid is needed in an emergency situation, larger-than-normal opioid doses may be required, which could cause potentially serious side effects, such as severe respiratory depression (slow and shallow breathing).