Vivactil Drug Interactions

If alcohol, arrhythmia medications, or other tricyclic antidepressants are taken with Vivactil, drug interactions may occur that could lead to an increased risk of side effects. To help minimize these risks, tell your healthcare provider about all other medicines you may be taking. Other drugs that can cause Vivactil drug interactions include anticholinergic medications, tramadol, cimetidine, and thyroid medications.

 

Vivactil Drug Interactions: An Overview

 Vivactil® (protriptyline hydrochloride) can potentially interact with many medicines. Some of the medicines that may lead to Vivactil drug interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Arrhythmia medications, including:
o Amiodarone (Cordarone®)
o Disopyramide (Norpace®)
o Dofetilide (Tikosyn®)
o Flecainide (Tambocor®)
o Ibutilide (Corvert®)
o Propafenone (Rythmol®)
o Quinidine
o Sotalol (Betapace®)
  • Cimetidine (Tagamet®)
     
  • Cisapride (Propulsid®)
     
  • Monoamine oxidase inhibitors (MAOIs), including:
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
  • Pressors, including:
o Dopamine (Intropin®)
o Dobutamine (Dobutrex®)
o Epinephrine (Adrenalin®, EpiPen®)
o Norepinephrine (Levophed®)
  • Thyroid medications, including:
o Liothyronine (Cytomel®)
o Liotrix (Thyrolar®)
o Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
o Thyroid (Armour® Thyroid, Nature-Throid®)
(Vivactil Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;