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Drug Interactions With Vilazodone

CYP 3A4 Inhibitor Medications
The body breaks down vilazodone using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining vilazodone with one of these drugs may increase the level of vilazodone in your body, increasing your risk for side effects. Your healthcare provider may decrease your vilazodone dose if you take it with a CYP 3A4 inhibitor.
 
Diuretics
Vilazodone can cause low blood sodium levels (hyponatremia). Taking it with a diuretic may increase your risk for this side effect. Talk to your healthcare provider before taking these medications together. In addition, combining vilazodone with torsemide may increase the level of torsemide in your blood, potentially increasing your risk for side effects. Talk to your healthcare provider before taking these medications together.
 
Fentanyl
Taking vilazodone with fentanyl can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Intravenous Methylene Blue
Taking vilazodone with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Lithium
Taking vilazodone with lithium may increase your risk for a serious reaction called serotonin syndrome. Although this reaction is quite rare, it can be dangerous. Talk to your healthcare provider before taking these medications together. Also, seek immediate medical care if you develop any symptoms of serotonin syndrome (see Precautions and Warnings With Vilazodone).
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Vilazodone Drug Information

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