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What Is Trazodone ER Used For?

How Does Trazodone ER Work?

It is not entirely clear how trazodone ER works. There are no other medications that work exactly like it (other than the short-acting version of trazodone). Trazodone ER acts on a specific chemical within the brain known as serotonin. Serotonin is one of several chemicals used to send messages in between the nerves; but, when serotonin levels become unbalanced, it can cause a variety of conditions, including depression.
Trazodone ER helps to block the reuptake of serotonin (so that more serotonin is available for the nerves in the brain), which returns the serotonin back to its "normal" levels. However, unlike selective serotonin reuptake inhibitors (SSRIs), trazodone may also block certain serotonin receptors.

Trazodone ER Uses in Children

Trazodone ER is not approved for use in children (usually defined as individuals under the age of 18 years old). It is not known if this medication is safe or effective for children.

Is Trazodone ER Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend trazodone ER for something other than depression (this would be known as an "off-label" use). Based on off-label uses of short-acting trazodone (Desyrel®), possible off-label uses of trazodone ER might include the treatment of the following conditions:
It is possible that the extended-release properties of this drug might not make it a good choice for some of these off-label uses (for instance, taking this medication for insomnia might lead to excessive daytime drowsiness).
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Trazodone ER Drug Information

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