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Trazodone ER Dosage

For the treatment of depression, the suggested starting dosage of trazodone ER is 150 mg once daily at bedtime. If necessary, your healthcare provider can increase this amount by 75 mg every three days. The maximum dosing of this medication is 375 mg daily. Do not suddenly stop taking this drug, as withdrawal symptoms may occur.

An Introduction to Dosing With Trazodone ER

The dose of trazodone ER (Oleptro™) that your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to trazodone ER
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.

Trazodone ER Dosage for Depression

The recommended starting trazodone ER dosage for depression treatment in adults is 150 mg once daily at bedtime. Your healthcare provider may increase your dose by 75 mg every three days, if necessary, up to a maximum of 375 mg once daily at bedtime.

General Information on Taking Trazodone ER

Some considerations for people taking trazodone ER include the following:
  • This medication comes in tablet form. It is taken by mouth, usually at bedtime.
  • You should take trazodone ER on an empty stomach.
  • Do not crush, chew, or dissolve the extended-release tablets, as this will cause the medication to be released too quickly. You must swallow them whole. You may cut or break the tablets in half along the score line, if necessary, to achieve the proper dose (this will not interfere with the extended-release properties of the tablets).
  • Make sure to take this medication at the same time each day, to keep an even level of the medication in your blood.
  • For the medication to work properly, it must be taken as prescribed. Do not suddenly stop taking it, as withdrawal symptoms could occur.
  • If you are unsure about anything related to your trazodone ER dosage, please talk with your healthcare provider, nurse, or pharmacist.
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