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Side Effects of Trazodone ER

In clinical studies, commonly reported trazodone ER side effects included headaches, drowsiness, and dry mouth. In most cases, these reactions are typically minor and easily treated. However, contact your healthcare provider right away if you notice more serious symptoms, such as hallucinations, difficulty breathing, or suicidal behavior.

An Introduction to Side Effects With Trazodone ER

As with any medicine, trazodone ER (Oleptro™) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with trazodone ER. Your healthcare provider can discuss a more complete list with you.)
 

Serious Trazodone ER Side Effects

Some side effects with trazodone ER are potentially serious and should be reported immediately to your healthcare provider. Although generally rare, some of these side effects are actually fairly common. These include but are not limited to:
 
  • Suicidal thoughts or behavior (see Antidepressants and Suicide)
  • A painful erection of the penis that does not go away (priapism)
  • Fast heart rate or an irregular heart rhythm (arrhythmia)
  • Lightheadedness, dizziness, and/or fainting, which may be signs of low blood pressure
  • Chest palpitations
  • Signs of serotonin syndrome (a rare but dangerous problem associated with medications like trazodone ER) such as:
     
    • Confusion or other mental changes
    • A rapid heart rate
    • Nausea
    • Vomiting
    • Diarrhea
    • Hallucinations
    • Blood pressure changes
    • Overactive reflexes
    • Fever
    • Shivering
    • Shakiness
    • Agitation
    • Sweating
    • Seizures
    • Coma
 
  • Signs of low sodium levels in the blood (hyponatremia), such as:
     
    • Headaches
    • Difficulty concentrating, memory problems, or confusion
    • Unsteadiness or falling
    • Hallucinations
    • Fainting
    • Seizures
    • Coma
 
  • Signs of an allergic reaction, such as:
     
    • An unexplained rash
    • Itching
    • Hives
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
 
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