Drug Interactions With Tranylcypromine

A number of medicines can potentially cause drug interactions with tranylcypromine, including many over-the-counter cough, cold, or allergy products; stimulants; other antidepressants; and blood pressure medications. Tranylcypromine drug interactions may lead to an increased risk of developing dangerous side effects like extremely high blood pressure, low blood pressure, or seizures.

 

Tranylcypromine Drug Interactions: An Introduction

Tranylcypromine sulfate (Parnate®) can potentially interact with many medicines. Because there are so many tranylcypromine drug interactions that can be very dangerous, it is important to check with your healthcare provider before taking any medications, whether prescription or over-the-counter. Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking tranylcypromine. Some of the medicines that may lead to tranylcypromine interactions include:
 
o Dextromethorphan (Robitussin DM® and many others)
o Naphazoline (various nasal and eye drops, such as Visine-A®)
o Oxymetazoline (various nasal and eye drops, such as Afrin®)
o Phenylephrine (Sudafed PE® and many others)
o Propylhexedrine (Benzedrex®)
o Pseudoephedrine (Sudafed® and many others)
  • Narcotics, such as codeine, hydrocodone, morphine, and many others
  • Pressors, including:
o Dopamine
o Ephedrine
o Epinephrine (Adrenalin®, EpiPen®)
o Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
o Levonordefrin (Carbocaine® with Neo-Cobefrin®)
o Midodrine (Orvaten™, ProAmatine®)
o Norepinephrine (Levophed®)
  • Stimulants, such as:
o Dextroamphetamine (Dexedrine®, Dexedrine Spansules®)
o Phentermine (Adipex-P®, Ionamin®)
o Amitriptyline and chlordiazepoxide (Limbitrol®)
o Amitriptyline and perphenazine (Etrafon®)
(Drug Interactions With Tranylcypromine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;