Tofranil PM Drug Interactions

When certain medications are taken together with Tofranil PM, drug interactions may occur. Some of the medicines that may potentially cause Tofranil PM interactions include cimetidine, barbiturates, methylphenidate, and pressors. Drug interactions with Tofranil PM can increase your risk of developing suicidal thoughts or a dangerous arrhythmia called QT prolongation, among other things.

Tofranil PM Drug Interactions: An Introduction

 Tofranil PM® (imipramine pamoate) can potentially interact with many other medicines. Some of the medicines that may lead to Tofranil PM interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:

 

 

  • Arrhythmia medications, including:

 

    • Amiodarone (Cordarone®)
    • Disopyramide (Norpace®)
    • Dofetilide (Tikosyn®)
    • Flecainide (Tambocor®)
    • Ibutilide (Corvert®)
    • Propafenone (Rythmol®)
    • Quinidine
    • Sotalol (Betapace®)

 

  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

 

 

  • Phenothiazine medications, including:

 

 

 

    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)

 

 

  • Thyroid medications, including:

 

 

 

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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