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Tofranil PM Drug Interactions

Barbiturates
Taking Tofranil PM with barbiturates can increase the risk of side effects of both Tofranil PM and barbiturates (such as drowsiness or dizziness). Also, barbiturates may decrease the level of Tofranil PM in your blood, perhaps making it less effective. If you are taking Tofranil PM with a barbiturate, your healthcare provider may need to adjust your doses of these medications.
 
Blood Pressure Medications
Tofranil PM can make certain blood pressure medications, such as clonidine (Catapres®), less effective. Also, taking Tofranil PM with high blood pressure medications may increase your chances of developing low blood pressure (hypotension). Talk with your healthcare provider before taking Tofranil PM with a blood pressure medication.
 
Buspirone (BuSpar)
Because combining Tofranil PM with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine (Tagamet)
Taking Tofranil PM with cimetidine can raise the level of Tofranil PM in your blood, increasing your chances of side effects. If you are taking Tofranil PM with cimetidine, your healthcare provider may need to adjust your doses of these medications.
 
Fentanyl
Combining Tofranil PM with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking Tofranil PM with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Lithium
Combining Tofranil PM with lithium may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
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Tofranil PM Drug Information

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