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Tofranil PM Dosage

For most adults who are beginning depression treatment with Tofranil PM, dosage recommendations start at 75 mg once a day. Depending on how you respond to the medication, your healthcare provider can increase your daily dose up to 300 mg. Lower doses are usually recommended for teenagers or elderly people, but since the lowest Tofranil PM strength is 75 mg, teens and elderly people should start with Tofranil (which is available in lower strengths). Make sure to take your Tofranil PM dose at the same time each day to maintain even drug levels in your system.

Tofranil PM Dosage: An Overview

The dose of Tofranil PM® (imipramine pamoate) that your healthcare provider prescribes will vary depending on a number of factors, including:
  • Your age
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Tofranil PM Dosing for Depression

The recommended starting Tofranil PM dosage for depression treatment is 75 mg once a day at bedtime. If needed, your healthcare provider may increase your Tofranil PM dose up to 300 mg total per day. Although most people take Tofranil PM once a day, your healthcare provider may recommend taking it more often, especially if you are taking a higher dose.
For the treatment of teenage depression or depression in elderly people, lower doses are recommended. However, because the lowest available strength of Tofranil PM is 75 mg, it is recommended that teens or elderly people start with Tofranil (not Tofranil PM), which comes in lower strengths.
If you do not take your Tofranil PM as scheduled, take your missed dose as soon as you remember. However, if you usually take your dose at night, you may not want to make up the missed dose, due to the risk of drowsiness if Tofranil PM is taken during the day. Also, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of Tofranil PM.
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