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Thorazine and Pregnancy

Previous animal studies involving Thorazine and pregnancy suggest that the medication may increase the risk of miscarriages and other complications. However, other studies suggest that the drug does not cause problems when it is used by pregnant women. If you are taking Thorazine and pregnancy occurs, be sure to tell your healthcare provider.

Is Thorazine Safe During Pregnancy?

Thorazine® (chlorpromazine hydrochloride) may not be safe for women who are pregnant. This is based on previous animal studies, which have suggested that Thorazine may cause problems during pregnancy.

Thorazine and Pregnancy Category C

The U.S. Food and Drug Administration (FDA) uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a Pregnancy Category C rating.
Studies of Thorazine in pregnant rodents suggest that the drug may increase the risk of miscarriages or other problems. However, Thorazine has been used for decades to treat morning sickness and psychiatric illness in pregnant women. Several observational studies suggest that Thorazine does not increase the risk of birth defects in humans. It is important to remember that the full risks of using Thorazine during pregnancy are not known.
A pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the pregnant woman outweigh any possible risks to the unborn child.
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