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Known as a "typical antipsychotic," thiothixene (Navane) is a drug used to treat schizophrenia. While the drug is often effective at controlling symptoms, it is not a cure for schizophrenia. The drug comes in the form of a capsule and is usually taken one to three times daily. Some possible side effects of the drug include tremors, muscle tension, and a feeling of internal jitteriness.

What Is Thiothixene?

Thiothixene (Navane®) is a prescription medicine known as a "typical antipsychotic" that has been licensed to treat schizophrenia.

Who Makes Thiothixene?

Thiothixene is manufactured by Pfizer, Inc.
(Click What Is Thiothixene Used For? for more information on what thiothixene is used for, including possible off-label uses.)

How Does Thiothixene Work?

Thiothixene belongs to a group of medications called typical (or first-generation) antipsychotic medications. In particular, it is part of a group of medications called thioxanthines, which are very similar to phenothiazines (another group of antipsychotic medications). It is not entirely known precisely how thiothixene works. However, it is known that thiothixene blocks or lessens the effects of dopamine, a chemical in the brain. Dopamine may be elevated in people with schizophrenia.
Thiothixene is not a cure for schizophrenia. It only helps to control symptoms (see Symptoms of Schizophrenia).

When and How to Take Thiothixene

Following are some general considerations for when and how to take thiothixene:
  • Thiothixene comes in capsule form. It is usually taken by mouth one to three times a day.
  • It does not matter if you take thiothixene with or without food. If the drug bothers your stomach, try taking it with food.
  • Thiothixene should be taken at the same time(s) each day to maintain even levels of the drug in your blood.
  • For thiothixene to work properly, it must be taken as prescribed. Thiothixene will not work if you stop taking it.
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