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Precautions and Warnings With Thiothixene

It is important to understand the precautions and warnings with thiothixene before starting the drug. For example, thiothixene can impair your ability to drive a car or operate heavy machinery. In addition, the drug can increase your risk of liver damage, eye damage, and seizures. Those who have a blood disorder, those who are allergic to the drug, and those who are in a coma are among the people who should not take thiothixene at all.

Thiothixene: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking thiothixene (Navane®) if you have:
 
Also let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant
  • Drink alcohol.
     
You should also be sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Some Precautions and Warnings With Thiothixene

Some warnings and precautions to be aware of with thiothixene include:
 
  • The U.S. Food and Drug Administration (FDA) has issued a special warning (a "black box warning") about the use of thiothixene in elderly people with dementia (a condition involving confusion; disorientation; and a loss of memory, intellect, and judgment) or psychosis. Elderly people with dementia (Alzheimer's disease is the most common form of dementia) who are treated with antipsychotics (such as thiothixene) are more likely to die (of various causes) than those who were not treated with those medications. Thiothixene is not approved to treat dementia or dementia-related psychosis, and caution should be used before using it in elderly people with dementia.
 
  • Thiothixene can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:

 

    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias).
Tell your healthcare provider right away if you think you might have NMS.
  • Thiothixene can cause tardive dyskinesia -- a condition involving unusual, uncontrollable body or face movements -- in some people. The condition can become permanent (even if thiothixene is stopped). The best way to prevent it from becoming permanent is to tell your healthcare provider right away if you notice any abnormal movements (including abnormal movements of the tongue) while taking thiothixene.
     
  • Thiothixene can impair your mental or physical abilities to drive a car or operate heavy machinery. Make sure you know how thiothixene affects you before you do any activities that require mental concentration or physical coordination.
     
  • Thiothixene can increase the risk of liver damage or eye damage. During treatment with thiothixene, be sure to let your healthcare provider know if you have signs of liver damage (such as yellow eyes or skin) or any vision changes.
     
  • Thiothixene can cause a drop in blood pressure (hypotension). This can cause a person to have lightheadedness or dizziness, or to faint. Tell your healthcare provider if you have any of these symptoms when standing. Hypotension can be especially dangerous in people with heart disease or congestive heart failure (CHF). Combining alcohol with thiothixene can also increase the risk of hypotension (see Alcohol and Navane).
     
  • Thiothixene may increase the risk of seizures. Before starting thiothixene, tell your healthcare provider if you have epilepsy or a history of seizures.

 

  • Antipsychotics (like thiothixene) have been reported to cause low white blood cells. Let your healthcare provider know if you develop frequent or persistent infections, as this may be a sign of low white blood cells. If you already have a low white blood cell count (or have had such a problem in the past), your healthcare provider should monitor your white blood cell count frequently during the first few months you take thiothixene. 

 

  • Thiothixene is considered a pregnancy Category C medication. This means that it may not be safe to take during pregnancy. Be sure to talk with your healthcare provider about the risks and benefits of using thiothixene during pregnancy (see Navane and Pregnancy).
     
  • It is not known if thiothixene passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using thiothixene (see Navane and Breastfeeding for more information).
     
  • Thiothixene can interact with certain other medications (see Drug Interactions With Thiothixene).
 
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