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Drug Interactions With Sublingual Buprenorphine

Taking certain drugs with sublingual buprenorphine may result in potentially dangerous interactions. Some of these complications can increase your risk for side effects, such as difficulty breathing, memory loss, and drowsiness. Alcohol, antidepressants, and benzodiazepines are among the products that can lead to negative reactions when taken with sublingual buprenorphine.

An Overview of Sublingual Buprenorphine Interactions

Sublingual buprenorphine (Subutex®) may react with a number of other medications. Some of the drugs that can lead to interactions with sublingual buprenorphine include but are not limited to:
  • Alcohol
  • Benzodiazepines, such as:
  • CYP 3A4 inducer medications, such as:
  • CYP 3A4 inhibitor medications, such as:
  • Medications that cause drowsiness, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
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Sublingual Buprenorphine Information

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