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Drug Interactions With Sublingual Buprenorphine

Drug Interactions With Sublingual Buprenorphine Explained

The following sections explain in detail the potentially negative reactions that can occur when sublingual buprenorphine is combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while using sublingual buprenorphine could increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while using sublingual buprenorphine.
 
Benzodiazepines
Combining sublingual buprenorphine with a benzodiazepine may increase the risk for serious problems, including death, particularly in the case of abuse or overdose. Normally, there is a limit known as a "ceiling" as to how much sublingual buprenorphine can negatively affect breathing. However, benzodiazepines may increase this limit, allowing for dangerously slow or irregular breathing. Do not combine sublingual buprenorphine with a benzodiazepine without your healthcare provider's approval and supervision.
 
CYP 3A4 Inducer Medications
The liver breaks down sublingual buprenorphine using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining sublingual buprenorphine with one of these drugs may decrease the level of sublingual buprenorphine in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure sublingual buprenorphine is working effectively if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The liver breaks down sublingual buprenorphine using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining sublingual buprenorphine with one of these drugs may increase the level of sublingual buprenorphine in your body, increasing your risk for serious side effects, including drowsiness, confusion, and breathing difficulty. Your healthcare provider may monitor you more closely for side effects if you take sublingual buprenorphine with a CYP 3A4 inhibitor.
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Sublingual Buprenorphine Information

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