Serzone
® (
nefazodone hydrochloride) is a prescription medicine used for the treatment of
depression (also known as major depression or clinical depression).
Serzone was originally manufactured by Bristol-Myers Squibb. However, Bristol-Myers Squibb voluntarily stopped making the medication, due to concerns of liver toxicity
(see Serzone and Liver Failure). Generic versions are still available and are made by a few manufacturers.
It is not entirely clear how Serzone works.
No other medications work exactly like it. Serzone acts on specific chemicals within the brain known as serotonin and norepinephrine. These chemicals are used to send messages between nerves; when levels become unbalanced, however, it can cause a variety of conditions, including depression. Serzone helps to block the reuptake of serotonin and norepinephrine so that more is available for the nerves in the brain, returning the serotonin back to its "normal" levels. However, unlike selective serotonin reuptake inhibitors (
SSRIs), Serzone may also block certain types of serotonin receptors.
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