Serzone Drug Interactions (Cont.)

 
Haloperidol (Haldol)
Serzone may increase the level of haloperidol in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your haloperidol dose.
 
Monoamine Oxidase Inhibitors (MAOIs)
You should not take Serzone if you have taken an MAOI within the past two weeks, due to the possibility of life-threatening side effects. Also, you should not take an MAOI if you have taken Serzone within the past seven days.
 
Pimozide (Orap)
You should not take pimozide and Serzone together. Serzone can increase the level of pimozide in your blood, which increases the risk of a dangerous irregular heart rhythm called QT prolongation.
 
Statins
Serzone should not be taken with certain stains, including atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor, Vytorin). Serzone greatly increases the level of these statins in your blood, increasing your risk of dangerous side effects. However, this does not apply to fluvastatin (Lescol®), pravastatin (Pravachol®), or rosuvastatin (Crestor®).
 
Tacrolimus (Prograf)
Serzone can increase the level of tacrolimus in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor the level of tacrolimus in your blood.
 
Triazolam (Halcion)
Serzone can greatly increase the level of triazolam in your blood, increasing your chance of side effects. In general, these two medications should not be taken together, especially in elderly people. In the rare circumstance that it is necessary to combine these two medications, the triazolam dose should be reduced by at least 75 percent.
 
(Serzone Drug Interactions Continued: Page 4)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;