Drug Interactions With the Selegiline Transdermal Patch

Because there are a number of potentially dangerous drug interactions with the selegiline transdermal patch, be sure to tell your healthcare provider about all of the medications you are taking before starting the antidepressant. Some of the medicines that can potentially interact with the selegiline transdermal patch include narcotics, cold medications, and blood pressure medicines. Drug interactions with the selegiline transdermal patch can increase the risk of dangerously high blood pressure, seizures, and other dangerous side effects.

 

An Introduction to Drug Interactions With the Selegiline Transdermal Patch

The selegiline transdermal patch (Emsam®) can potentially interact with many other medicines. Because there are so many drug interactions with the selegiline transdermal patch that can be very dangerous, it is important to check with your healthcare provider before taking any medication, whether prescription or over-the-counter. Make sure to tell all of your healthcare providers (including dentists and surgeons) that you are taking the selegiline transdermal patch. Some of the medicines that may lead to interactions with the selegiline transdermal patch include:
 

 

    • Dextromethorphan (Robitussin DM® and many others)
    • Naphazoline (various nasal and eye drops, such as Visine-A®)
    • Oxymetazoline (various nasal and eye drops, such as Afrin®)
    • Phenylephrine (Sudafed PE® and many others)
    • Propylhexedrine (Benzedrex®)
    • Psuedoephedrine (Sudafed® and many others)

 

 

 

  • Narcotics, such as codeine, hydrocodone, morphine, and many others
  • Oxcarbazepine (Trileptal®)
  • Propoxyphene (Darvon®, Darvocet®, Balacet®)
  • Pressors, including:

 

    • Dopamine
    • Ephedrine
    • Epinephrine (Adrenalin®, EpiPen®)
    • Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
    • Levonordefrin (Carbocaine with Neo-Cobefrin®)
    • Midodrine (Orvaten®, ProAmatine®)
    • Norepinephrine (Levophed®) 

 

 

 

  • Stimulants, such as:

 

 

 

 

(Drug Interactions With the Selegiline Transdermal Patch Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;