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Drug Interactions With the Selegiline Transdermal Patch

Pressors
Do not take pressors and the selegiline transdermal patch within two weeks of each other due to the risk of dangerous side effects, such as high blood pressure.
 
Sibutramine (Meridia)
You should not take sibutramine and the selegiline transdermal patch within 14 days of each other due to the risk of dangerous side effects.
 
SSRI or SNRI Medications
Due to the risk of serious side effects, you should not take SSRIs or SNRIs together with the selegiline transdermal patch. Because certain SSRIs or SNRIs can stay in your body for quite a while, make sure to ask your healthcare provider when you can start taking an SSRI or SNRI after stopping the selegiline transdermal patch (or the other way around).
 
Stimulants
Do not take stimulants and the selegiline transdermal patch within two weeks of each other due to the risk of dangerous side effects, such as high blood pressure.
 
St. John's Wort
You should not take St. John's wort while taking the selegiline transdermal patch (or if you have taken the selegiline transdermal patch within the past 14 days) due to the risk of dangerous side effects.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
You should not take tramadol while taking the selegiline transdermal patch (or if you have taken the selegiline transdermal patch within the past 14 days) due to the risk of dangerous side effects.
 
Tricyclic Antidepressants
Do not take tricyclic antidepressants and the selegiline transdermal patch within two weeks of each other due to the risk of dangerous side effects, such as high blood pressure or seizures.
 
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Selegiline Transdermal Patch (Emsam)

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