SAM-e Side Effects

Nausea, insomnia, and loss of appetite are some of the more commonly reported SAM-e side effects. These side effects are more likely to occur with a higher dosage of the supplement. Several less common -- but potentially serious -- side effects of SAM-e are also possible and require immediate medical attention, including restlessness, panic attacks, and suicidal thoughts or behavior.

 

Does SAM-e Cause Side Effects?

As with any medication or supplement, side effects are possible with S-adenosyl-L-methionine (SAM-e). Many people assume that natural products, such as SAM-e, are always free of side effects. However, this is simply not the case. Any supplement that has medicinal properties may also have side effects.
 

Common Side Effects of SAM-e

Some of the common SAM-e side effects include:
 
As you might expect, side effects are more common with a higher SAM-e dosage.
 

SAM-e Side Effects to Report

Some side effects of SAM-e, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Anxiety, agitation, or panic attacks
  • Hostility or aggressiveness
  • Engaging in unusual or dangerous activities
  • Restlessness or inability to sit still
  • Extreme elation or feeling of happiness that may switch back and forth with a depressed or sad mood
  • Other unusual changes in behavior
  • Suicidal thoughts or behavior
  • Parkinson's disease symptoms, such as a tremor (SAM-e could theoretically cause or worsen these symptoms)
  • Signs of an allergic reaction, such as:
 
    • Itching
    • Hives
    • Rash
    • Wheezing
    • Difficulty breathing
    • Swelling of the mouth or throat.
 
(SAM-e Side Effects Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;