Diarrhea or constipation, dry mouth, sweating, and headaches are some of the most commonly reported SAM-e side effects. The risk of developing side effects is increased with higher doses of the supplement. While most side effects of SAM-e are merely bothersome, some are potentially serious and should be reported to your healthcare provider, such as anxiety, restlessness, and unusual changes in behavior.
(Click SAM-e Side Effects for a more detailed list of side effects that may occur, including other common side effects and rare side effects that require immediate medical attention.)