Reliable evidence suggests that SAM-e may be effective for depression, arthritis, and intrahepatic cholestasis. However, not enough research has been done to know if it is effective for other uses.
(Click Does SAM-e Work? for more information.)
Although less information is available on the dosing of supplements, such as SAM-e, compared to drugs, some information about dosing is available based on clinical studies and years of practical experience with the supplement.
(Click SAM-e Dosage for more information.)
Although it is a "natural" product, SAM-e can still cause side effects. Some of the more commonly reported side effects include:
(Click SAM-e Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
SAM-e may interact with other supplements or medications (see SAM-e Drug Interactions).