Considerations for people taking SAM-e include the following:
It is important to find a trustworthy and reputable SAM-e manufacturer. Some dietary supplements have been found to be contaminated with heavy metals or prescription drugs, and some have been found to contain much more or much less of the featured ingredient than their label states. Your pharmacist is a good resource for information about which manufacturers are most reputable.
Different forms of SAM-e may be more potent than others, since the body may absorb them differently. Be sure to follow the instructions for your specific product.
Some SAM-e tablets are enteric-coated, which means they have a special coating to prevent them from dissolving until they reach the small intestine, which is presumably where SAM-e is absorbed.
If you are unsure about anything related to your dosage or SAM-e dosing in general, please talk with your healthcare provider.