Benefits of SAM-e (Cont.)

How Does SAM-e Work?

It is not clear exactly how SAM-e works for depression treatment or other uses. SAM-e causes several changes in the brain that may be responsible for its antidepressant effects.
 
SAM-e probably works in several different ways for arthritis treatment. It may have pain-relieving and anti-inflammatory effects, and may stimulate the growth and repair of cartilage in joints.
 
People with intrahepatic cholestasis often have a decreased ability to make SAM-e, which can cause numerous problems and can further worsen liver problems. SAM-e supplements can help make up for this decrease in production.
 
SAM-e may work for AIDS-related myelopathy because SAM-e levels in the spinal fluid of people with AIDS are often low.
 

SAM-e Use in Children

Since children may be more susceptible to toxicities of dietary supplements, do not give your child any supplement, including SAM-e, without discussing it with your child's healthcare provider.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;