People who experience depression, insomnia, or asthma may be interested in trying saffron. This herbal remedy is made from the saffron crocus flower and is often used as an expensive spice. However, when used as a supplement, saffron is claimed to have several health benefits. Although some studies suggest that saffron may be effective at treating depression, more research is needed to determine if it is effective for any use. It is important to know that it is possible (and potentially quite dangerous) to overdose on saffron. Seek immediate medical care if you think you have taken too much.