You may experience some or none of the saffron side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a supplement that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking saffron. You should also let your healthcare provider know if you develop something that "just does not seem right." While it may not be a side effect of saffron, your healthcare provider will be able to diagnose and treat the problem.