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Revia Warnings and Precautions

If you have problems with depression, suicidal thoughts, or kidney disease, talk to your healthcare provider about whether it is appropriate for you to take Revia. Other warnings and precautions with this drug apply to people using certain medications and women who are pregnant or breastfeeding. You should not take it if you have liver failure, acute hepatitis, or opioid withdrawal symptoms.

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to taking Revia® (naltrexone) if you have:
  • Used a narcotic (opioid), alcohol, or street drug in the past 7 to 10 days
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Depression or have had depression in the past
  • Had thoughts of suicide or harming yourself
  • Symptoms of drug or alcohol withdrawal
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Revia

Some warnings and precautions to be aware of prior to taking Revia include the following:
  • You should carry identification, such as a medical card or medical bracelet, to alert medical personnel that you are being treated with Revia. This will help ensure you receive appropriate care in the case of an emergency. You can get a medical card from your healthcare provider.
  • Revia may cause liver damage, especially when taken in higher-than-recommended doses. Let your healthcare provider know if you develop liver problems during treatment, such as:
    • Abdominal (stomach) pain
    • Pale-colored stool
    • Dark urine
    • Yellowing of the skin or whites of the eyes (jaundice).
  • Revia can cause withdrawal symptoms when taken with opioids. Therefore, you must be opioid free, including prescription narcotic medications and heroin, for 7 to 10 days (for most opioids) before starting treatment. For long-acting opioids such as buprenorphine or methadone, you need to wait an even longer time (two weeks) before starting Revia. Your healthcare provider may want to do certain tests, such as a urine test, to check for opioids in your system. Let him or her know if you are having symptoms of opioid withdrawal, such as:
    • Anxiety or restlessness
    • Insomnia
    • Yawning
    • Sweating
    • Excessive watering of the eyes
    • Runny nose
    • Goosebumps
    • Fever, shaking, and chills
    • Muscle aches
    • Nausea and vomiting
    • Abdominal (stomach) cramps.
Opioid withdrawal caused by Revia can be much more severe than "normal" opioid withdrawal. Normal symptoms can be extremely unpleasant, but are not usually dangerous. Opioid withdrawal caused by Revia, on the other hand, may be serious enough to require hospitalization.
  • This medicine blocks the effects of opioids, including the "high" feelings and the pain-relieving effects. Do not try to overcome this by taking large amounts of opioids or heroin, as doing so is extremely dangerous and may result in a coma or death.
  • Because Revia blocks the effects of opioids, if you need medication for pain, cough, or diarrhea during treatment, you will need to take a nonopioid-containing medicine.
  • You may be more sensitive to the effects of opioids after you have been treated with this product. Using opioids in the amounts you used before treatment could cause serious harm, including death. Make sure your healthcare providers know if you have been treated with Revia, even after treatment is complete.
  • This medication should be used cautiously in people with liver or kidney disease. Make sure your healthcare provider knows if you have these conditions.
  • People with substance abuse are at an increased risk for suicide, and Revia does not reduce this risk. Please seek immediate help if you have suicidal thoughts or thoughts of hurting yourself or ending your life.
  • Revia is just one part of a comprehensive treatment program for drug or alcohol dependence. Your healthcare provider may recommend other types of treatment, such as counseling or support groups. 
  • Revia passes through breast milk. Therefore, if you are breastfeeding or plan to start, you should discuss this with your healthcare provider prior to taking the drug (see Revia and Breastfeeding).
  • Revia is a pregnancy Category C medication, which means it may not be safe for use during pregnancy, although the full risks are currently unknown (see Revia and Pregnancy).
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