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Quetiapine XR Dosing

The recommended starting quetiapine XR dosage for treating schizophrenia is 300 mg once daily, typically taken in the evening. If necessary, your healthcare provider will increase your dose within a few days. For bipolar disorder, the dosage will depend on whether you are currently experiencing mania or depression (or are currently on a maintenance dose between depressive and manic episodes).

An Introduction to Quetiapine XR Dosing

The dose of quetiapine XR (Seroquel XR®) your healthcare provider recommends will vary depending on a number of factors, including:
  • The medical condition being treated
  • The severity of your condition
  • Other medical conditions you may have
  • Other medications you may currently be taking.
As always, do not adjust your quetiapine XR dose unless your healthcare provider specifically instructs you to do so.

Quetiapine XR Dosing for Schizophrenia

The recommended starting quetiapine XR dose for treating schizophrenia is quetiapine XR 300 mg once daily, preferably in the evening. Generally, your healthcare provider will increase your dose quickly within a few days, up to quetiapine XR 800 mg once daily if needed.

Quetiapine XR Dosing for Bipolar Disorder

The recommended quetiapine XR dosage for bipolar disorder depends on whether you currently have depression, mania, or neither. The recommended dosages are as follows:
  • Bipolar depression episodes:
    • Day 1 -- 50 mg once daily
    • Day 2 -- 100 mg once daily
    • Day 3 -- 200 mg once daily
    • Day 4 -- 300 mg once daily
  • Bipolar mania episodes:


    • Day 1 -- 300 mg once daily
    • Day 2 -- 600 mg once daily
    • Day 3 -- 400 to 800 mg once daily
  • Maintenance (after the depression or mania episode has improved) -- continue at the same dose you were stabilized on during treatment of the episode.


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Quetiapine XR Drug Information

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