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Quetiapine XR Dosing

Quetiapine XR Dosing for Depression

The recommended starting quetiapine XR dose for treating depression (when used in combination with an antidepressant) is quetiapine XR 50 mg once daily, preferably in the evening. Generally, your healthcare provider will increase your dose to 150 mg daily on your third day. The maximum dose of quetiapine XR that has been studied for this use is 300 mg daily. 


Quetiapine XR Dosing for Special Situations

Elderly individuals and people with liver problems should be started with a low quetiapine XR dosage (50 mg once daily). The dose can be increased daily in increments of 50 mg per day.
People who are switching from regular quetiapine to quetiapine XR can take the equivalent total daily dose, except just once a day. For instance, if you took quetiapine 200 mg three times daily, the equivalent dose would be quetiapine XR 600 mg once daily.
If you stop taking quetiapine XR and need to start taking it again, it is usually recommended that you start back at a low dose and work your way back up (just as if you had never taken it before).

General Quetiapine XR Dosing Information

Some considerations for people taking quetiapine XR include:
  • Quetiapine XR comes in tablet form. It is usually taken by mouth once a day, typically in the evening.
  • While quetiapine XR can be taken on an empty stomach or with a light meal (300 calories or less), it should not be taken with a large, fatty meal. Taking quetiapine XR with too much food can increase the amount of quetiapine XR in your blood, increasing your risk of side effects.
  • Quetiapine XR tablets are extended release and should not be crushed, split, broken, or chewed. They should be swallowed whole.
  • Quetiapine XR should be taken at the same time each day to maintain even levels of the drug in your blood.
  • For quetiapine XR to work properly, it must be taken as prescribed. Quetiapine XR will not work if you stop taking it.
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