Drug Interactions With Quetiapine XR (Cont.)

 
Certain Antibiotics or Antifungals
Taking quetiapine XR with some antibiotics or antifungal medications may increase the level of quetiapine XR in your blood, increasing your risk of quetiapine XR side effects. Your healthcare provider may need to lower your quetiapine XR dosage.
 
Cimetidine (Tagamet)
Taking quetiapine XR with cimetidine may increase the level of quetiapine XR in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your quetiapine XR dosage, although this is not always necessary.
 
Divalproex (Depakote, Depakote ER)
Taking quetiapine XR with divalproex may increase the level of quetiapine XR in your blood, increasing your risk of side effects. Combining these medications can also decrease the level of divalproex in your blood, possibly decreasing its effectiveness. Your healthcare provider may need to lower your quetiapine XR dosage and increase your divalproex dosage.
 
Lorazepam (Ativan)
Taking lorazepam with quetiapine XR can increase the level of lorazepam in your blood, increasing your risk of lorazepam side effects. Your healthcare provider may need to lower your lorazepam dosage.
 
Phenytoin (Dilantin, Phenytek)
Taking quetiapine XR with phenytoin can decrease the level of quetiapine XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your quetiapine XR dosage.
 
Thioridazine (Mellaril)
Taking quetiapine XR with thioridazine can decrease the level of quetiapine XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your quetiapine XR dosage.
 

Final Thoughts on Drug Interactions With Quetiapine XR

It is possible that not every drug interaction with quetiapine XR was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the quetiapine XR drug interactions that may apply to you.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;