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Drug Interactions With Quetiapine XR

Alcoholic Beverages
It is not recommended that you drink alcohol while taking quetiapine XR. Taking alcohol and quetiapine XR together may cause unwanted side effects (see Alcohol and Seroquel).
 
Certain Antibiotics or Antifungals
Taking quetiapine XR with some antibiotics or antifungal medications may increase the level of quetiapine XR in your blood, increasing your risk of quetiapine XR side effects. Your healthcare provider may need to lower your quetiapine XR dosage.
 
Cimetidine (Tagamet)
Taking quetiapine XR with cimetidine may increase the level of quetiapine XR in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your quetiapine XR dosage, although this is not always necessary.
 
Divalproex (Depakote, Depakote ER)
Taking quetiapine XR with divalproex may increase the level of quetiapine XR in your blood, increasing your risk of side effects. Combining these medications can also decrease the level of divalproex in your blood, possibly decreasing its effectiveness. Your healthcare provider may need to lower your quetiapine XR dosage and increase your divalproex dosage.
 
Lorazepam (Ativan)
Taking lorazepam with quetiapine XR can increase the level of lorazepam in your blood, increasing your risk of lorazepam side effects. Your healthcare provider may need to lower your lorazepam dosage.
 
Medications That Cause QT Prolongation
Many medications, including quetiapine XR, have a tendency to cause a change in the heart rhythm known as QT prolongation. If severe enough, this can be fatal. Combining quetiapine XR with other medications with this potential increases the risk. Check with your healthcare provider before combining quetiapine XR with other QT-prolonging medications.
  
Phenytoin (Dilantin, Phenytek)
Taking quetiapine XR with phenytoin can decrease the level of quetiapine XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your quetiapine XR dosage.
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Quetiapine XR Drug Information

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