Side Effects of Phenelzine (Cont.)

Serious Side Effects of Phenelzine

Some side effects with phenelzine, while not as common, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Dangerously high blood pressure (called a hypertensive crisis). Signs of a hypertensive crisis include:
 
    • Headaches
    • Feelings of a rapidly or forcefully beating heart (palpitations)
    • Sore or stiff neck
    • Nausea or vomiting
    • Sweating, with a high fever (or sometimes with cold, clammy skin)
    • Sensitivity to light
    • Rapid heart rate (tachycardia) or low heart rate (bradycardia)
    • Chest pain or throat tightness
    • Dilated (wide open) pupils.
 
  • Low blood pressure (hypotension). Signs of low blood pressure include:
 
    • Dizziness
    • Lightheadedness
    • Fainting.
 
  • Hepatitis (liver damage). Signs of liver damage include:
 
    • Yellow eyes or skin
    • Upper-right abdominal pain (near the liver)
    • Dark urine
    • Digestive problems.
 
  • Confusion, delusions, or hallucinations.
 
 
  • Hostility or aggressiveness.
 
  • Engaging in unusual or dangerous activities.
 
  • Restlessness or inability to sit still.
 
  • Extreme elation or feeling of happiness that may switch back and forth with a depressed or sad mood.
 
  • Other unusual changes in behavior.
 
 
  • Signs of an allergic reaction, including:
 
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 
(Side Effects of Phenelzine Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;