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Drug Interactions With Phenelzine

Narcotics
Taking phenelzine with narcotics can increase your chance of side effects (such as drowsiness or low blood pressure). Talk to your healthcare provider before taking these medications together.
 
Pressors
Do not take pressors and phenelzine within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure.
 
Reserpine
Do not take reserpine and phenelzine within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure.
 
Sibutramine
You should not take sibutramine and phenelzine within 14 days of each other, due to the risk of dangerous side effects.
 
SSRI or SNRI Medications
Do not take SSRIs or SNRIs with phenelzine, due to the risk of serious side effects. Because certain SSRIs or SNRIs can stay in your body for quite a while, make sure to ask your healthcare provider when you can start taking an SSRI or SNRI after stopping phenelzine (or the other way around).
 
Stimulants
Do not take stimulants and phenelzine within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure.
 
Tolcapone
Combining tolcapone and phenelzine can lead to dangerous side effects. Do not take these medications together or within two weeks of each other.
 
Tricyclic Antidepressants
Taking tricyclic antidepressants and phenelzine together can increase your risk of side effects. Special care should be taken when using these medications in combination or within 10 days of each other. Some sources suggest that these medications should never be taken together.
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