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Drug Interactions With Phenelzine

Cough, Cold, and Allergy Products
Taking phenelzine with many cough, cold, and allergy products (including eye drops or nasal products) can increase your risk of dangerous side effects, such as high blood pressure. Most of these products should never be taken with phenelzine. Always check with your healthcare provider before taking any cough, cold, or allergy medicines.
 
Cyclobenzaprine
Taking cyclobenzaprine and phenelzine together can increase your risk of side effects. Special care should be taken when using these medications in combination or within 10 days of each other. Some sources suggest that these medications should never be taken together.
 
Disulfiram
There is some evidence that taking disulfiram with phenelzine may cause dangerous side effects. Talk to your healthcare provider before taking these medications together.
 
Entacapone
Combining entacapone and phenelzine can lead to dangerous side effects. Do not take these medications together or within two weeks of each other.
 
Levodopa
Do not take levodopa and phenelzine within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure.
 
Methyldopa
Do not take methyldopa and phenelzine within two weeks of each other, due to the risk of dangerous side effects, such as high blood pressure.
 
Meperidine
You should not take meperidine while taking phenelzine (or even if you have taken phenelzine within the past 14 days), due to the risk of dangerous side effects.
 
Miscellaneous Antidepressants
Combining phenelzine with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors
Taking phenelzine with other MAOIs can increase your chance of developing dangerous side effects. Do not take phenelzine and other MAOIs within two weeks of each other.
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Phenelzine Drug Information

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