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Drug Interactions With Phenelzine

Phenelzine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when phenelzine is combined with any of the drugs listed above.
 
Apraclonidine
You should not use aproclonidine eye drops while taking phenelzine, due to the risk of dangerously high blood pressure (hypertension).
 
Atomoxetine
Atomoxetine and phenelzine should not be taken together or within two weeks of each other, due to the risk of dangerous side effects.
 
Barbiturates
Phenelzine can increase certain side effects of barbiturates (such as drowsiness). Your healthcare provider may need to decrease your barbiturate dose to prevent this interaction from occurring.
 
Blood Pressure Medications
Taking phenelzine with high blood pressure medications can increase your risk of low blood pressure (hypotension). Always check with your healthcare provider before taking phenelzine with blood pressure medications.
 
Brimonidine
You should not use brimonidine eye drops while taking phenelzine, due to the risk of dangerously high blood pressure.
 
Buspirone
You should not take buspirone while taking phenelzine (or even if you have taken phenelzine within the past 14 days), due to the risk of dangerously high blood pressure.
 
Caffeine
You should use caffeine sparingly while taking phenelzine, due to the risk of dangerously high blood pressure. Be aware that many foods and medicines (such as "stay-awake" products and migraine products) contain caffeine.
 
Carbamazepine
Taking carbamazepine and phenelzine together can increase your risk of side effects. Special care should be taken when using these medications in combination or within 10 days of each other.
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Phenelzine Drug Information

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