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Perphenazine Dosing

Perphenazine dosing guidelines call for an initial dose of 4 mg to 8 mg, taken three times daily, when treating schizophrenia. When treating severe nausea and vomiting, the recommended starting dose is 8 mg to 16 mg (divided into two or more smaller doses). Besides the condition being treated, other existing medical conditions and other medications you are taking are among the factors that can affect your perphenazine dosing.

An Introduction to Perphenazine Dosing

The dose of perphenazine (Trilafon®) that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As always, do not adjust your perphenazine dose unless your healthcare provider specifically instructs you to do so.
 

Perphenazine Dosing for Schizophrenia

The recommended starting dose of perphenazine for schizophrenia is perphenazine 4 mg to 8 mg three times daily (although people under medical supervision in a hospital may start at higher dosages). Ideally, your healthcare provider will quickly lower your dose once your symptoms are under control.
 

Perphenazine Dosing for Nausea and Vomiting

The recommended dose of perphenazine for severe nausea and vomiting is perphenazine 8 mg to 16 mg per day (split up into two or more smaller doses). Some people may need a higher dose to control their nausea and vomiting initially (up to 24 mg per day), but the dose should quickly be reduced if possible.
 

General Information on Dosing With Perphenazine

Considerations for people taking perphenazine include the following:
 
  • The medication comes in tablet form. It is usually taken by mouth two to four times a day.
     
  • You can take perphenazine with or without food. If the medication bothers your stomach, try taking it with food.
     
  • Perphenazine should be taken at the same times each day to maintain an even level in your blood.
     
  • For the medication to work properly, it must be taken as prescribed. Perphenazine will not work if you stop taking it.
     
  • If you are unsure about anything related to your dosage or to perphenazine dosing in general, talk with your doctor, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider (see Trilafon Withdrawal).
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Information About Perphenazine

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