Drug Interactions With Perphenazine

If certain medications are taken together, there is a potential for negative drug interactions. With perphenazine, these interactions can increase your risk of side effects or perhaps make perphenazine less effective. Drug interactions with perphenazine can occur if the medication is combined with alcohol, barbiturates, or certain seizure medications. To prevent these interactions from occurring, your healthcare provider may adjust your dosages.

 

An Introduction to Drug Interactions With Perphenazine

Perphenazine (Trilafon®) can potentially interact with a number of other medicines. Some of the medicines that may lead to interactions with perphenazine include:
 
  • Alcohol
 
  • Barbiturates, including:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Certain anticonvulsants, including:
 
 
 
 
  • Narcotics or opiates, such as morphine or oxycodone (Oxycontin®)
 
  • Pindolol
 
 
  • Rifamycin antibiotics, including:
 
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Rifapentine (Priftin®)
 
 
 
(Drug Interactions With Perphenazine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;