Perphenazine Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
perphenazine is combined with any of the drugs listed above.
Alcohol
Barbiturates
Perphenazine should not be combined with large doses of barbiturates due to an increased risk of sedation and other problems.
Certain Anticonvulsants
Taking perphenazine with certain anticonvulsants (
seizure medications) can increase your risk of drowsiness and may increase your risk of
seizures. Talk to your healthcare provider before using these medications together.
Certain SSRI Antidepressants
Combining perphenazine with certain
SSRI antidepressants can increase the amount of perphenazine in your blood, potentially increasing your risk of
side effects of perphenazine. Your healthcare provider may need to decrease your perphenazine dosage to prevent this interaction from occurring.
Narcotics and Opiates
Perphenazine should not be combined with large doses of narcotics and opiates due to an increased risk of sedation and other problems.
Pindolol
Combining perphenazine with pindolol may increase the amount of both medications in your blood, potentially increasing your risk of side effects. Talk to your healthcare provider before using these medications together.
Propranolol
Taking perphenazine with
propranolol may increase the amount of both medications in your blood, possibly increasing your risk of side effects. Talk to your healthcare provider before using these medications together.
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