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Drug Interactions With Paroxetine Mesylate

Tricyclic Antidepressants
Combining paroxetine mesylate with a tricyclic antidepressant can increase the level of the tricyclic antidepressant in your blood. Sometimes these medications may be taken together to treat depression or other conditions.
 
However, if they are used together, your healthcare provider will likely monitor you closely. Your healthcare provider may need to lower your dose of the tricyclic antidepressant if you take it with paroxetine mesylate.
 
Triptans
Taking paroxetine mesylate with triptan medications may increase your risk for a serious and potentially dangerous reaction called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Seek immediate medical care if you develop any symptoms of serotonin syndrome.
 
Tryptophan
Combining paroxetine mesylate with tryptophan may increase your risk for a serious and potentially dangerous reaction called serotonin syndrome. Talk to your healthcare provider before taking tryptophan with paroxetine mesylate. Also, seek immediate medical care if you develop any symptoms of serotonin syndrome.
 

Final Thoughts

Paroxetine mesylate may react with many other medications -- far too many to discuss in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions with paroxetine mesylate that may apply to you.
 
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Paroxetine Mesylate Drug Information

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