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Drug Interactions With Paroxetine Mesylate

Pimozide
Pimozide and paroxetine mesylate should not be taken together, as the combination may cause a dangerous irregular heart rhythm called QT prolongation.
 
Risperidone
Paroxetine mesylate can increase the level of risperidone in your blood, increasing your risk of side effects. Talk to your healthcare provider before taking these medications together. He or she may need to decrease your risperidone dosage.
 
SSRI or SNRI Antidepressants
Taking paroxetine mesylate with other SSRI or SNRI antidepressants can increase your risk for a serious and potentially dangerous reaction called serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, such as:
 
  • Confusion
  • A rapid heartbeat
  • Sweating
  • Muscle spasm or rigidity
  • Difficulty walking
  • Diarrhea.
 
St. John's Wort
Taking paroxetine mesylate with St. John's Wort can increase your risk for a serious and potentially dangerous reaction called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome.
 
Tamoxifen
Tamoxifen must be activated in the liver before it can work in the body. Paroxetine mesylate can reduce this activation, perhaps making tamoxifen less effective. Check with your healthcare provider before taking these drugs together.
 
Tramadol
Taking paroxetine mesylate with tramadol may increase your risk for a serious and potentially dangerous reaction called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Seek immediate medical care if you develop any symptoms of serotonin syndrome.
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Paroxetine Mesylate Drug Information

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