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Drug Interactions With Paroxetine Mesylate

Medications That "Thin" the Blood
Taking paroxetine mesylate with medications that thin the blood can increase your risk for bleeding. Talk to your healthcare provider before taking paroxetine mesylate with any medication that thins the blood.
 
Miscellaneous Antidepressants
Combining paroxetine mesylate with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Paroxetine mesylate should not be taken with an MAOI. These medications should also not be taken within two weeks of each other. Taking these drugs together can cause life-threatening reactions.
 
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Taking paroxetine mesylate with NSAIDs can increase your risk of stomach bleeding. Talk to your healthcare provider before taking these medications together. Contact your healthcare provider if you develop any signs of bleeding while taking paroxetine mesylate, including:
 
  • Weakness
  • Stomach pains
  • Black, tarry stools
  • Vomit that looks like coffee grounds.
 
Phenothiazines
Paroxetine mesylate can increase the level of phenothiazine medications in your blood, increasing your risk of side effects, such as significant drowsiness or movement problems. It is recommended that paroxetine mesylate not be taken with thioridazine in particular, as this combination may lead to a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking paroxetine mesylate with any phenothiazine medication.
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Paroxetine Mesylate Drug Information

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