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Drug Interactions With Paroxetine Mesylate

Cyproheptadine
Cyproheptadine may make paroxetine mesylate less effective at treating depression. If you take these medications together, your healthcare provider may choose to closely monitor your depression symptoms to make sure paroxetine mesylate is working for you.
 
Fentanyl
Combining paroxetine mesylate with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Galantamine
Paroxetine mesylate may increase the amount of galantamine in your body, increasing your risk for side effects. If you take these medications together, your healthcare provider may need to monitor you for side effects of galantamine, and you may need a lower dose.
 
Intravenous Methylene Blue
Taking paroxetine mesylate with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Linezolid
Taking paroxetine mesylate with linezolid may increase your risk for a serious and potentially dangerous reaction called serotonin syndrome. Symptoms of serotonin syndrome include confusion, hallucination, feeling faint, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Seek immediate medical care if you develop any symptoms of serotonin syndrome.
 
Lithium (Eskalith, Lithobid)
Taking paroxetine mesylate with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
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Paroxetine Mesylate Drug Information

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