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Drug Interactions With Paroxetine Mesylate

Atomoxetine
Paroxetine mesylate can increase the levels of atomoxetine in your body, increasing your risk for side effects. If you take these medications together, you may need a lower dose of atomoxetine.
 
Beta Blockers
Paroxetine mesylate may increase the levels of certain (but not all) beta blockers in your body. This may lead to low blood pressure (hypotension). If you take paroxetine mesylate with a beta blocker, your healthcare provider may choose to monitor your blood pressure and pulse closely, and lower your beta blocker dosage if needed.
 
Buspirone (BuSpar)
Because combining paroxetine mesylate with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine
Taking cimetidine with paroxetine mesylate can increase the level of paroxetine mesylate in your blood, increasing your risk for side effects. Your healthcare provider may need to lower your paroxetine mesylate dosage or may suggest an alternative to cimetidine.
 
CYP 2D6 Inhibitor Medications
The body breaks down paroxetine mesylate using enzymes in the liver known as CYP 2D6 enzymes. Medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes.
 
Combining paroxetine mesylate with one of these CYP 3A4 inhibitors may increase the level of paroxetine mesylate in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects in this situation, and may need to decrease your paroxetine mesylate dose if you take it with a CYP 2D6 inhibitor.
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Paroxetine Mesylate Drug Information

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