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Drug Interactions With Paroxetine Mesylate

Paroxetine Mesylate and Serotonin Syndrome

Several of the known interactions with paroxetine mesylate are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 

More Information on Drug Interactions With Paroxetine Mesylate

The following sections explain in detail the potentially negative interactions that can occur when paroxetine mesylate is combined with any of the drugs listed above.
 
Alcohol
Taking paroxetine mesylate with alcohol might increase your risk of serious side effects, such as severe drowsiness, confusion, or memory loss. The manufacturer recommends avoiding alcohol while taking this medication.
 
Amphetamines or Amphetamine-like Medications
Taking paroxetine mesylate with amphetamines may increase your risk for a serious and potentially dangerous reaction called serotonin syndrome. Symptoms of serotonin syndrome include:
 
  • Confusion
  • Hallucination
  • A rapid heartbeat
  • Feeling faint
  • Sweating
  • Muscle spasm or rigidity
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Also, call your healthcare provider right away if you develop any symptoms of serotonin syndrome.
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Paroxetine Mesylate Drug Information

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