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Paliperidone Side Effects

Paliperidone Side Effects to Report

There are a number of side effects with paliperidone that you should report to your healthcare provider. These include but are not limited to:
  • Signs of diabetes, such as high blood sugar, increased thirst, frequent urination, and/or extreme hunger (see Invega and Diabetes)
  • Large or rapid weight gain
  • Anxiety
  • High blood pressure (hypertension)
  • Very severe constipation
  • Dizziness or fainting when going from a sitting or lying-down position to standing
  • A penile erection that does not go away (priapism)
  • Easy bruising or bleeding
  • Frequent infections
  • Difficulty swallowing 
  • Unexplained breast enlargement or breast discharge
  • Signs or symptoms of neuroleptic malignant syndrome, which can include:


    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • An increased heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias)


  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.

A Summary of Paliperidone Side Effects

It is possible that you may experience some or none of the paliperidone side effects explained above. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking paliperidone. You should also let your healthcare provider know if you develop something that "just does not seem right" during treatment with paliperidone. While it may not be a side effect of the medication, your healthcare provider will be able to diagnose and treat the problem.
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Paliperidone (Invega)

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