You should talk with your healthcare provider prior to taking paliperidone if you have:
- A narrowing of the gastrointestinal tract (such as a stricture)
- Kidney disease, including kidney failure (renal failure)
- Alzheimer's disease or other forms of dementia
- Low blood pressure (orthostatic hypotension)
- A certain arrhythmia called long QT syndrome
- Heart disease, congestive heart failure (CHF), or other heart problems
- Any allergies, including allergies to food, dyes, or preservatives.
Also let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Invega and Pregnancy)
- Breastfeeding (see Invega and Breastfeeding)
- Drink alcohol regularly (see Alcohol and Invega).
You should also make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Paliperidone for more information on this topic, including information on who should not take this medication.)
Paliperidone belongs to a group of medications called atypical (or second-generation) antipsychotic medications. It is not entirely known how paliperidone works for the treatment of schizophrenia. However, it is known that the drug blocks or lessens the effects of several chemicals in the brain. These brain chemicals (such as dopamine and serotonin) may be elevated in people with schizophrenia.
Paliperidone is not a cure for schizophrenia or schizoaffective disorder. It only helps to control symptoms (see Symptoms of Schizophrenia).