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Paliperidone Dosing

For the treatment of schizophrenia in adults, dosing for oral paliperidone typically starts at 6 mg once a day. If needed, your healthcare provider may increase the dose up to 12 mg. People with kidney disease may need to start at a lower dosage. To maintain even levels of the medicine in your blood, make sure to take your dosage at the same time each day.

An Introduction to Paliperidone Dosing

The dose of paliperidone (Invega®) your healthcare provider recommends will vary depending on a number of factors, including:
 
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As always, do not adjust your paliperidone dose unless your healthcare provider specifically instructs you to do so.
 

Oral Paliperidone Dosing for Schizophrenia or Schizoaffective Disorder in Adults

The recommended starting paliperidone dose for schizophrenia or schizoaffective disorder treatment in adults is 6 mg once daily in the morning. If needed, your healthcare provider can increase your dose up to 12 mg once daily in the morning.
 
People with kidney disease may need a lower paliperidone dose (such as paliperidone 1.5 or 3 mg once daily).
 

Oral Paliperidone Dosing for Schizophrenia in Adolescents

The recommended starting paliperidone dose for schizophrenia in adolescents (12 to 17 years of age) is 3 mg once daily in the morning. If needed, your healthcare provider can increase the dose slowly.
  

Injectable Paliperidone Dosing for Schizophrenia

The recommended starting injectable paliperidone dose for schizophrenia is 234 mg injected on the first day of treatment. A dose of 156 mg is usually used one week later. After that, a once-monthly dose of 117 mg is standard, although some people may need much higher or lower monthly doses. Your healthcare provider will inject the medication into the muscle of your upper arm or buttock (although the first two doses should be given in the upper arm only).
 
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Paliperidone (Invega)

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