Drug Interactions With Paliperidone

A number of drugs can increase a person's risk of developing a dangerous irregular heart rhythm called QT prolongation. A few of these drugs include certain antibiotics, arrhythmia medications, and phenothiazine medicines. Because paliperidone can also increase the risk of QT prolongation, it should generally not be combined with any of the medications discussed above. In order to reduce the chances of drug interactions with paliperidone, be sure to tell your healthcare provider (prior to taking paliperidone) about every other drug you are taking.

 

An Introduction to Drug Interactions With Paliperidone

Paliperidone (Invega®) can potentially interact with a number of other medicines. Some of these medicines that may lead to paliperidone interactions include:
 
  • Alfuzosin (Uroxatral®)
  • Amoxapine
  • Apomorphine (Apokyn®)
  • Chloroquine (Aralen®)
  • Certain anesthetics
  • Certain antibiotics, including:

 

    • Ciprofloxacin (Cipro®, Cipro XR®)
    • Clarithromycin (Biaxin®, Biaxin XL®)
    • Erythromycin (Ery-Tab®)
    • Gemifloxacin (Factive®)
    • Levofloxacin (Levaquin®)
    • Mefloquine (Lariam®)
    • Moxifloxacin (Avelox®)
    • Norfloxacin (Noroxin®)
    • Ofloxacin (Floxin®)
    • Telithromycin (Ketek®)
    • Troleandomycin (Tao®)

 

  • Certain arrhythmia medications, including:

 

    • Amiodarone (Cordarone®)
    • Disopyramide (Norpace®, Norpace CR®)
    • Dofetilide (Tikosyn®)
    • Flecainide (Tambocor®)
    • Ibutilide (Corvert®)
    • Procainamide (Procanbid®)
    • Propafenone (Rhythmol®)
    • Quinidine
    • Sotalol (Betapace®)

 

  • Certain phenothiazine medications, including:

 

 

 

(Drug Interactions With Paliperidone Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;